Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease

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Paradoxical SAPHO syndrome observed during anti-TNFα therapy for Crohn’s disease

Currently, anti-TNFα antibodies are used to treat Crohn's disease. We report on a 45-year-old Japanese female with Crohn's disease developing SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome following exposure to the anti-TNFα antibody adalimumab. Initially, adalimumab induced remission, but the patient showed SAPHO syndrome 11 weeks following the start of adalimumab the...

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ژورنال

عنوان ژورنال: Biologics: Targets and Therapy

سال: 2017

ISSN: 1177-5491

DOI: 10.2147/btt.s134508